Hypokalemic Periodic Parlaysis Associated with Adrenal Adenoma in a Patient with Conn’s Syndrome: A Case Report

Abstract

Introduction: Hypokalemic paralysis secondary to Conn’s syndrome is rare. The most common presentation of this condition is hypertension, which may be asymptomatic or range from mild to severe to refractory. Case Report: A 34-year-old hypertensive female presented with acute onset of lower limb weakness. She reported two similar episodes in the past. She had profound hypokalemia and further evaluation revealed high aldosterone and low renin levels, suggesting an adrenal adenoma. She was managed with antihypertensives and spironolactone. After CT confirmation of a right adrenal adenoma, she underwent surgery. She showed significant improvement in both her symptoms and laboratory parameters after surgery, and is doing well on her follow-up. Conclusion: This case illustrates that a high index of suspicion leads to early recognition and timely management of an unusual and potentially severe clinical manifestation of primary hyperaldosteronism in the form of hypokalemic periodic paralysis, especially in the setting of unexplained hypertension.